منابع مشابه
Cohesion fatigue
What is cohesion fatigue? Cohesion fatigue is the asynchronous separation of chromatids in cells that are arrested or delayed at metaphase. In normal anaphase, synchronous chromatid separation is followed by cytokinesis and mitotic exit. In contrast, after cohesion fatigue, cells usually remain locked in mitosis for some time after chromatids separate. Cohesion fatigue requires the mechanical f...
متن کاملCohesion Fatigue Induces Chromatid Separation in Cells Delayed at Metaphase
BACKGROUND Chromosome instability is thought to be a major contributor to cancer malignancy and birth defects. For balanced chromosome segregation in mitosis, kinetochores on sister chromatids bind and pull on microtubules emanating from opposite spindle poles. This tension contributes to the correction of improper kinetochore attachments and is opposed by the cohesin complex that holds the sis...
متن کاملCohesion Metrics
We consider ways of measuring the cohesion of program fragments based upon techniques for program slicing, following the work of Ott et al 12, 2, 13, 11, 10]. The approach is based on the idea that the intersection of a program's slices represents that part of the fragment which is cohesive. We produce cohesion metrics that are structurally identical to those of Ott and Thuss 13], the diierence...
متن کاملChromatid cohesion
The equal distribution of chromosomes during mitosis is dependent on the maintenance of chromatid cohesion. This cohesion firmly tethers the sister chromatids of a replicated chromosome to one another until its two kinetochore regions, which lie on opposite sides of the centromere, acquire the proper bipolar attachment to the forming spindle. Then, shortly after the last kinetochore in the cell...
متن کاملSocial Cohesion
Investigators interested in developing a general theory of social cohesion are confronted with a complex body of work that involves various definitions of social cohesion, specialized literatures on particular dimensions of social cohesion (e.g., membership turnover, organizational commitment, categorical identifications, interpersonal attachments, network structures), and lines of inquiry focu...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2013
ISSN: 0960-9822
DOI: 10.1016/j.cub.2013.08.017